Protein name:
Neprilysin ;
Alternative:
Enkephalinase ;Atriopeptidase ;Skin fibroblast elastase (SFE) ;Neutral endopeptidase 24.11 (NEP;Neutral endopeptidase) ;
CD:
CD10 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity). Involved in the degradation of atrial natriuretic factor (ANF).
Subcellular Location:
Cell membrane
Single-pass type II membrane protein
Protein Attributes:
50:
MGRSESQMDI | TDINAPKPKK | KQRWTPLEIS | LSVLVLLLTI | IAVTMIALYA |
100:
TYDDGICKSS | DCIKSAARLI | QNMDASAEPC | TDFFKYACGG | WLKRNVIPET |
150:
SSRYSNFDIL | RDELEVILKD | VLQEPKTEDI | VAVQKAKTLY | RSCINESAID |
200:
SRGGQPLLTL | LPDIYGWPVA | SQNWEQTYGT | SWTAEKSIAQ | LNSKYGKKVL |
250:
INFFVGTDDK | NSTQHIIHFD | QPRLGLPSRD | YYECTGIYKE | ACTAYVDFMI |
300:
SVARLIRQEQ | RLPIDENQLS | LEMNKVMELE | KEIANATTKP | EDRNDPMLLY |
350:
NKMTLAKLQN | NFSLEINGKP | FSWSNFTNEI | MSTVNINIQN | EEEVVVYAPE |
400:
YLTKLKPILT | KYSPRDLQNL | MSWRFIMDLV | SSLSRNYKES | RNAFRKALYG |
450:
TTSETATWRR | CANYVNGNME | NAVGRLYVEA | AFAGESKHVV | EDLIAQIREV |
500:
FIQTLDDLTW | MDAETKKKAE | EKALAIKERI | GYPDDIISNE | NKLNNEYLEL |
550:
NYKEEEYFEN | IIQNLKFSQS | KQLKKLREKV | DKDEWISGAA | VVNAFYSSGR |
600:
NQIVFPAGIL | QPPFFSARQS | NSLNYGGIGM | VIGHEITHGF | DDNGRNFNKD |
650:
GDLVDWWTQQ | SANNFKDQSQ | CMVYQYGNFT | WDLAGGQHLN | GINTLGENIA |
700:
DNGGIGQAYR | AYQNYVKKNG | EEKLLPGLDL | NHKQLFFLNF | AQVWCGTYRP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
Rabbit
Mouse
ELISA Kit for Rat Neprilysin
ELISA Kit for Rat Neprilysin
ELISA Kit for Rat Neprilysin
ELISA Kit for Rat Neprilysin
ELISA Kit for Rat Neprilysin
CLIA Kit for Rat Neprilysin
CLIA Kit for Rat Neprilysin
CLIA Kit for Rat Neprilysin
CLIA Kit for Rat Neprilysin
CLIA Kit for Rat Neprilysin
Polyclonal Antibody for Rat Neprilysin
Polyclonal Antibody for Rat Neprilysin
Polyclonal Antibody for Rat Neprilysin
Polyclonal Antibody for Rat Neprilysin
Polyclonal Antibody for Rat Neprilysin
Monoclonal Antibody for Rat Neprilysin
Monoclonal Antibody for Rat Neprilysin
Monoclonal Antibody for Rat Neprilysin
Monoclonal Antibody for Rat Neprilysin
Monoclonal Antibody for Rat Neprilysin
Protein for Rat Neprilysin
Protein for Rat Neprilysin
Protein for Rat Neprilysin
Protein for Rat Neprilysin
Protein for Rat Neprilysin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Kidney .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACTIVE SITE ARG-103
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INHIBITION BY SIALORPHIN